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Article
February 20, 1926

CHOLESTEROL SYNTHESIS AND HYPERCHOLESTEROLEMIA

JAMA. 1926;86(8):571. doi:10.1001/jama.1926.02670340049027

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Abstract

In The Journal, Oct. 3, 1925, page 1066, an editorial appears entitled "The Synthesis of Cholesterol in the Body." It is indicated therein that feeding experiments have shown that cholesterol need not have its source exclusively in the diet.

We submit further evidence on this point in the form of Dezani's work (Arch. di farmacol. sper.12:4, 1914). He fed measured quantities of cholesterol to white mice, and on analyzing their entire carcasses, found that the total amount of cholesterol therein was greater than what could be explained on the basis of that ingested.

The subject of cholesterol synthesis comes to medical men by various avenues. Foremost among these are the various considerations associated with hypercholesterolemia, in connection with which certain tissue changes may come about or be experimentally induced. Some, notably the atheromatous aortas of rabbits, have been repeatedly and rather uniformly elicited, but others, such as xanthoma

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