In spite of all the precautionary methods, it is difficult to prevent the spread of bacillary dysentery in institutions for young children. If immunity to this disease could be produced, a material reduction in the morbidity and mortality of such institutions during the summer months would result.
Many workers 1 have shown by experiments on animals and men that protection against dysentery can be conferred by the use of vaccines. Shiga,2 Gibson,3 Vincent4 and Csernel5 have been successful by the subcutaneous administration of vaccines in lowering materially the incidence and mortality of the disease in certain epidemics. Their results indicate that protection is not conferred by dysentery vaccines in all cases. Among a large group of inoculated persons there are always certain ones who never develop immune bodies. From five days to three weeks must elapse before agglutinins are produced in most instances. The duration of
WILKINS L, WELLS HS. IMMUNIZATION OF CHILDREN AGAINST FLEXNER DYSENTERY. JAMA. 1924;82(20):1599–1601. doi:10.1001/jama.1924.02650460023010
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