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May 24, 1924


JAMA. 1924;82(21):1695-1696. doi:10.1001/jama.1924.02650470035017

The distribution in nature of substances comparable with pancreatic insulin has been studied by several investigators. The term "glucokinin" has been applied to certain of these, said to be derived from yeast and other vegetable sources. It is worth while, therefore, to call attention to the fact, well known to biochemists, that various chemical compounds have long been observed to be capable of lowering the content of sugar in the blood as insulin does. Macleod1 has properly given warning that, despite such experimental evidence for the reduction of hyperglycemia, great caution should be exercised in considering these products for clinical use until it is certain that they have no deleterious effects on the liver. It is possible also, he adds, that the substances merely stimulate the secretion of insulin from the pancreas of the animal into which they are injected, or serve as precursors for its production. If this is