Despite the great prevalence of arthritis, the destructive character of its lesions, and the incalculable amount of suffering and economic loss that it causes, the etiology of this widespread malady is still very much in doubt, and the foremost authorities fail to agree on any rational treatment by which its ravages may be controlled.
Animal experimentation has demonstrated that the early pathologic changes induced by arthritis are swelling and congestion of the synovial membrane, accompanied by increased growth and desquamation of the lining cells and infiltration of the membranes with lymphoid cells. This is soon followed by an exudation and, as the condition progresses, definite articular and periarticular changes take place, with the production of pain and limitation of motion, and the gradual increase of permanent deformity, which frequently results in the complete incapacity of the patient.
The different manifestations of arthritis have been variously classified, but it is rather
TURNBULL JA. THE RELATION OF ANAPHYLACTIC DISTURBANCES TO ARTHRITIS. JAMA. 1924;82(22):1757–1759. doi:10.1001/jama.1924.02650480013007
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