This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
In this laboratory study under the auspices of the Medical Research Council, the nasal mucosa of the rabbit was found highly susceptible to the virus of vaccinia. Immunity was produced by heated as well as by living virus. No difference was detected between the virus of the mild type (alastrim) and of the severe type of smallpox, except that virus from a confluent case of smallpox was decidedly more virulent than that of alastrim when the two were tested on the skin of the same monkey. Positive results with variola virus of both types were obtained in complement fixation and agglutination tests with antivaccinia serum.
Studies of the Viruses of Vaccinia and Variola. JAMA. 1926;86(12):896. doi:10.1001/jama.1926.02670380086046
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: