Edema has long presented one of the perplexing problems of pathology. It may appear when there is embarrassment of the peripheral circulation resulting from heart failure. It is observed in those forms of chronic parenchymatous nephritis to which the name nephrosis has been applied since 1905, when it was introduced by Friedrich Müller. The symptoms are frequently observed in acute glomerular nephritis. The specialist has likewise recognized the appearance of edema under far less definite conditions. Soda edema may follow extreme alkali therapy in diabetic acidosis; nutritional edema attends dietary restrictions and was particularly conspicuous in the central empires during the World War as war dropsy. Localized edema occurs at the site of inflammations; after some forms of intoxications, edema may arise either locally or generally; and in angioneurotic edema the possibility of a perversion of the nervous control of blood volume regulation is brought into consideration. With such a
CRITICAL CONSIDERATIONS OF EDEMA. JAMA. 1926;86(13):952–953. doi:10.1001/jama.1926.02670390032015
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