Alkalosis is the term that has been employed to cover those conditions which are associated with a shifting of the acid-base balance of the blood from the normal definitely to the alkaline side. Although this term has been used for several years, and a number of papers have appeared describing conditions in which an alkalosis no doubt existed, the data, with a very few exceptions, have been inconclusive for the reason that the pH of the blood was not ascertained. Our observations lead us to believe that alkalosis is a condition that is much more common than has ordinarily been supposed and has often been overlooked by the clinician.
In health, the blood is uniformly maintained at a constant slightly alkaline reaction (pH of about 7.4) through the influence of the bicarbonate, the phosphate and the proteins of the blood. The chlorid shift, whereby the chlorin ion may
KAST L, MYERS VC, SCHMITZ HW. CLINICAL CONDITIONS OF ALKALOSIS. JAMA. 1924;82(23):1858–1861. doi:10.1001/jama.1924.02650490032011