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June 7, 1924


JAMA. 1924;82(23):1858-1861. doi:10.1001/jama.1924.02650490032011

Alkalosis is the term that has been employed to cover those conditions which are associated with a shifting of the acid-base balance of the blood from the normal definitely to the alkaline side. Although this term has been used for several years, and a number of papers have appeared describing conditions in which an alkalosis no doubt existed, the data, with a very few exceptions, have been inconclusive for the reason that the pH of the blood was not ascertained. Our observations lead us to believe that alkalosis is a condition that is much more common than has ordinarily been supposed and has often been overlooked by the clinician.

In health, the blood is uniformly maintained at a constant slightly alkaline reaction (pH of about 7.4) through the influence of the bicarbonate, the phosphate and the proteins of the blood. The chlorid shift, whereby the chlorin ion may

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