In the paper on immunization against diphtheria with toxin that has been detoxified with sodium ricinoleate,1 a brief discussion of the action of soaps on bacterial toxins was given and references to previous publications were cited. We have therefore not deemed it necessary to repeat the discussion here.
In immunizing members of the human family against any bacterial toxin, it is necessary to have the immunizing material in a form that will give little or no reaction, as any immunizing method that is followed by a moderately severe reaction, either general or local, will not find favor with either the physician or the general public. In fact, when animal immunization against bacterial toxins was first begun, following the discovery of diphtheritic and tetanic toxins, it was found that the naked toxins were too toxic to be used in the preliminary injections. Efforts were therefore made to find some neutralizing
LARSON WP, HUENEKENS EJ, COLBY W. IMMUNIZATION AGAINST SCARLET FEVER: WITH TOXIN DETOXIFIED WITH SODIUM RICINOLEATE. JAMA. 1926;86(14):1000–1001. doi:10.1001/jama.1926.02670400010005
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