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April 24, 1926

Abhandlungen aus der Neurologie, Psychiatrie, Psychologie und ihren Grenzgebieten.

JAMA. 1926;86(17):1311. doi:10.1001/jama.1926.02670430053033

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The author first gives as background a general discussion of the clinical and histologic evidences for the possible curability of general paralysis. He takes up the Staussler Jakob theory that general paralysis histologically is usually a general nonspecific reaction to the spirochete or its toxic products, but that in certain cases evidences of a specific and beneficial tissue reaction in the form of miliary gummas are present. The author fails to consider Spielmeyer's probably correct interpretation of the supposed gummas as local accentuations of the general inflammatory process. The etiology is considered from all aspects. There is a short discussion of the relation of the spirochetes to the brain changes. All the existent theories as to the pathogenesis of general paralysis are given. Sixty-three full case reports show the effects of the immune serum treatment, which is the use of the serum of horses immunized over a period of two

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