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Clinical Trials Update
July 28, 2015

Thrombectomy After Stroke Improves 90-Day Outcomes

JAMA. 2015;314(4):331. doi:10.1001/jama.2015.8128

Two recent multicenter randomized clinical trials demonstrated that, compared with tissue plasminogen activator (tPA) alone, endovascular thrombectomy using the Solitaire stent retriever decreased severity of global disability (as measured on the modified Rankin scale) and improved rates of functional independence (score of 0-2 on the modified Rankin scale) at 90 days for some patients who had an acute ischemic stroke. Both studies included only patients who had a confirmed occlusion of the proximal anterior intracranial circulation and who did not have a large infarct.