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Article
January 21, 1933

AN UNUSUAL DISEASE OF THE BONE MARROW (OSSEOMYELODYSPLASIA)

Author Affiliations

CHICAGO
From the Children's Ward and the Pathological Department of the Presbyterian Hospital.

JAMA. 1933;100(3):162-167. doi:10.1001/jama.1933.02740030010003
Abstract

The clinical and anatomic characteristics of the disease of the bone marrow (osseomyelodysplasia) in a white boy, aged 7 years, to be described herein are of interest chiefly because we have been unable to correlate it with any of the distinctive bone marrow diseases. Myeloma, at first glance, seems to be the group that might possibly include our case because of the marked destruction of bone and the wide dissemination of the bone marrow alterations. Yet, as will be noted from its characteristics, this disease differs greatly from myeloma so far as the general characteristics of neoplasms are concerned. Of the diseases now included under the group name myeloma, erythroblastoma would be worthy of the most consideration; but this disease has nothing really in common with our case. The absence of hyperplasia of the usual potential accessory myeloid depots in the liver and spleen, together with the absence of an

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