It is generally recognized that neoarsphenamine prepared by different laboratories is more likely to vary in parasiticidal or curative activity than arsphenamine. For this reason the treatment of syphilis with neoarsphenamine may involve the regrettable error of employing a compound below the average in curative activity and therefore requiring some laboratory check or standard of spirocheticidal activity similar in principle to the standards established by the federal government in relation to toxicity.
This variation in the parasiticidal activity of neoarsphenamine, prepared by different laboratories and indeed observed to some extent in different lots prepared in the same laboratory, has been best detected by means of trypanocidal tests which yield rather sharply defined results capable of eliciting even minor differences in compounds. Unfortunately, however, the results of tests for spirocheticidal activity in the treatment of experimental syphilis of rabbits are less well defined, although still capable of detecting somewhat grosser variations
SCHAMBERG JF, KOLMER JA. TOXICITY AND PHYSICAL PROPERTIES OF NEOARSPHENAMINE OF DIFFERENT MANUFACTURE: A COMPARATIVE STUDY OF THE TOXICITY AND THE TRYPANOCIDAL AND SPIROCHETICIDAL PROPERTIES, WITH THE ADVISABILITY OF ESTABLISHING STANDARDS OF CURATIVE ACTIVITY. JAMA. 1933;100(3):180–184. doi:10.1001/jama.1933.02740030028010
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