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June 12, 1926


JAMA. 1926;86(24):1821-1824. doi:10.1001/jama.1926.02670500009004

The significance of albumin in the urine of apparently healthy children is still the subject of much discussion. Most of these cases are accidentally discovered in the routine examination of urine in schools, orphan asylums and dispensaries. Bright,1 in 1827, regarded albumin in the urine as definite evidence of kidney disease. This view was held until Ultzmann,2 in 1870, suggested the possibility of this urinary finding without an accompanying nephritis, and Leube,3 in 1877, proved that albumin is found in the urine of many apparently healthy people. Various theories have been advanced to account for this benign albuminuria. Hooker4 reviews the voluminous literature up to 1910. Post and Thomas5 and Lauener6 have summarized it up to 1923.

The frequency of the condition in children varies in the reports from different observers. Capitan7 reported the condition in 40 per cent of healthy children, Langstein