Following Epstein's1 paper stressing the relationship between the reduction in concentration of plasma protein and noncardiac edema and the value of a high protein diet in the treatment of such edema, numerous communications, both experimental and clinical, have appeared that have confirmed the soundness of his ideas. An excellent critical review of this subject with a comprehensive bibliography may be found in Leiter's2 monograph on nephrosis. As a result of such observations, the most widely accepted basic treatment of nephrotic edema has become the feeding of a high protein diet, together with restriction of salt and water, and the transfusion of whole blood or plasma.
In analytic studies to be published elsewhere, the limitations of such treatment will be discussed. It will suffice here to say that, in the more severe cases of nephrosis, loss of plasma albumin through the kidney continues to equal or exceed the maximum
HARTMANN AF, SENN MJE, NELSON MV, PERLEY AM. THE USE OF ACACIA IN THE TREATMENT OF EDEMA. JAMA. 1933;100(4):251–254. doi:10.1001/jama.1933.02740040019008
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