The intensive experimental study of suprarenal functions recently reported from several laboratories affords an added illustration of the great help that clinical medicine may derive from animal experimentation. The demonstration that loss of the cortex—in contrast to the extirpation of the adrenal medulla—results in symptoms quite characteristic of the manifestations of Addison's disease in man is paving the way to what may in due time become an adequate replacement therapy.1 One of the symptoms of adrenalectomy is a defect in carbohydrate metabolism. The alleviatory effects of administration of cortical extracts, such as have become available in the past few years, appear to be related to the restoration of a normal carbohydrate balance. In this connection Silvette2 suggests that cortical adrenal extracts increase the rate of glycolysis in the presence of normal defibrinated blood in vitro from 25 to 125 per cent above that found in the control tests.
RECENT INVESTIGATIONS OF ADRENAL FUNCTION. JAMA. 1933;100(4):261–262. doi:10.1001/jama.1933.02740040029015
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