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January 28, 1933


JAMA. 1933;100(4):270-271. doi:10.1001/jama.1933.02740040038020

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Gold Therapy in Tuberculosis  The treatment of pulmonary tuberculosis with gold salts continues to be a live topic of discussion among phthisiologists. A large number of these have called attention to untoward incidents and accidents which they have observed in connection with gold therapy and which, in their opinion, constitute contraindications to the use of the method. Tuberculous patients presenting an insufficiency of the organs through which the elimination of the gold is accomplished (liver, kidney, intestine) should be excluded from this treatment. The harmful effects bear chiefly on the components of the blood, the endothelium of the capillaries, and the reticulo-endothelial tissues. The accidents most commonly observed are agranulocytosis, purpura hemorrhagica, icterus, nephritis and aplastic anemia. The multiplicity and the variety of these accidents are explained, according to Professor Chevallier, by the selective attack, varying with the case, on the various constituent elements of the blood and of the

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