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February 4, 1933


Author Affiliations

San Francisco. Professor of Pharmacology, Stanford University School of Medicine

JAMA. 1933;100(5):357. doi:10.1001/jama.1933.02740050053028

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To the Editor:  —In the correspondence about "Methylene Blue as Antidote for Cyanide and Carbon Monoxide Poisoning" (The Journal, January 7, p. 59), my knowledge of the possible usefulness of methylene blue in the treatment of cyanide poisoning and my service to the San Francisco Department of Public Health have been referred to.The use of methylene blue (methylthionine chloride, U. S. P.) in the treatment of cyanide poisoning is not original with Mrs. Brooks. The antidotal action of this dye in cyanide poisoning was first demonstrated by Sahlin of Lund in 1926 (Skandinav. Arch. f. Physiol.47:284, 1926) and significantly established by Eddy of the University of Michigan in 1930 (J. Pharmacol. & Exper. Therap.39:271, 1930). Eddy states that "it [methylene blue] stimulated respiration when that was depressed by sodium cyanide to the point of enabling an animal to survive an otherwise fatal dose of cyanide."

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