This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
To the Editor:
—In the correspondence about "Methylene Blue as Antidote for Cyanide and Carbon Monoxide Poisoning" (The Journal, January 7, p. 59), my knowledge of the possible usefulness of methylene blue in the treatment of cyanide poisoning and my service to the San Francisco Department of Public Health have been referred to.The use of methylene blue (methylthionine chloride, U. S. P.) in the treatment of cyanide poisoning is not original with Mrs. Brooks. The antidotal action of this dye in cyanide poisoning was first demonstrated by Sahlin of Lund in 1926 (Skandinav. Arch. f. Physiol.47:284, 1926) and significantly established by Eddy of the University of Michigan in 1930 (J. Pharmacol. & Exper. Therap.39:271, 1930). Eddy states that "it [methylene blue] stimulated respiration when that was depressed by sodium cyanide to the point of enabling an animal to survive an otherwise fatal dose of cyanide."
Hanzlik PJ. METHYLENE BLUE AS ANTIDOTE FOR CYANIDE POISONING. JAMA. 1933;100(5):357. doi:10.1001/jama.1933.02740050053028
Customize your JAMA Network experience by selecting one or more topics from the list below.