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June 26, 1926


JAMA. 1926;86(26):1964-1968. doi:10.1001/jama.1926.02670520008003

The frequent complaints of disturbed menstruation brought to the clinician serve as a constant stimulus to him to seek the fundamental cause for these disturbances. In order to evaluate properly the disturbances of menstruation, one must first explain the normal periodic changes that occur in the genital organs. Up to the present time, explanations of these changes have lacked an extensive foundation of an experimental nature. There are, however, many observers keenly interested in the subject in both the laboratory and the clinic. From these sources valuable contributions are frequently appearing which bring nearer the final solution of the problem.

That the normal menstrual cycle is largely dependent on ovarian function is well established. The ovary cannot be considered alone, however, for evidences of interrelation of the ductless glands are ever present. The improved understanding of one gland aids the interpretation of the functions of others. The vastness of the