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June 26, 1926


JAMA. 1926;86(26):1995. doi:10.1001/jama.1926.02670520039019

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To the Editor:  —In answer to a query regarding sensitized bacterial vaccines (The Journal, April 24), a statement was made that "sensitized bacterial vaccines are objectionable because they may sensitize the injected person to the proteins in the animal serum with which the bacteria have been treated." Apparently it is assumed that sufficient animal protein must be present in a human dose of the vaccine to cause sensitiveness.Such vaccines (serobacterins) are sensitized with cattle serum, not horse serum. Also, sensitized bacterial vaccines are not a mixture of serum and vaccine, but the organisms after treatment with the serum are washed with salt solution, recentrifugalized, and finally diluted again in salt solution. The only free serum that could be present is that which clung mechanically to the organisms during the sensitization. The subsequent washing would act as a progressive dilution of this serum, and a calculation of this dilution shows

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