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Article
February 18, 1933

HYPERTENSION, OBESITY, VIRILISM AND PSEUDOHERMAPHRODITISM: AS CAUSED BY SUPRARENAL TUMORS

JAMA. 1933;100(7):463-466. doi:10.1001/jama.1933.02740070001001

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Abstract

Cortical suprarenal tumors are of unusual interest because of the changes in metabolism, the changes in distribution of hair, the hypertension, and the changes in the secondary sexual characteristics caused by them. In recent articles such changes have been ascribed to basophilic adenoma of the pituitary. If such observations are correct, and it seems they are, one is forced to the conclusion that similar or identical changes are caused by tumors of either of these glands. It must be borne in mind that the suprarenal is a compound gland and that the medulla plays no part in changes of the sexual organs. But tumors of the medulla do cause hypertension and brief consideration will be given to tumors of this type.

The symptoms of suprarenal cortical tumors are variable, depending on the sex, the time of onset, and the rapidity of the growth. Two syndromes have been described: (1) the

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