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Article
July 3, 1926

SUBSTITUTES FOR EPHEDRINE

JAMA. 1926;87(1):50. doi:10.1001/jama.1926.02680010050026

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Abstract

To the Editor:  —The experimental and clinical investigations of the action of ephedrine, reported by us separately in a number of recent publications, were carried out with ephedrine sulphate or hydrochloride, made in the laboratory of pharmacology of Peking Union Medical College according to the method described by one of us (Chen, K. K.: A Pharmacognostic and Chemical Study of Ma Huang [Ephedra Vulgaris Var. Helvetica], J. Am. Pharm. A. 14:191 [March] 1925). We have recently had some experience with a preparation of so-called ephedrine hydrochloride, which was sold by a druggist in Philadelphia who obtained it from an English drug house, the source and method of preparation being unknown. This sample of the drug was not effective clinically in the control of asthma in a patient who had been completely relieved by the Peking product (Miller). Experimentally it was capable of relaxing the bronchial spasm produced in pithed

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