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The studies which form the main excuse for this book have involved a stupendous amount of work in cutting serial sections, gross and microscopic, of many brains, together with the contiguous skull and soft tissues. It was the hope of the authors that in this manner they might add to our knowledge of the manner in which intracranial pyogenic diseases arise. The microscopic details and case reports, which are presented in tiresome and excessive detail, make up the bulk of the presentation. Nor is it possible to believe that anything of material value has been added by the microscopic investigations. From clinical and gross pathologic studies it is well known that pyogenic infections of the brain arise either by direct extension of contiguous infections or through the blood vessels, whether venous or arterial. As a matter of fact, the pathways of infections into the brain from venous sinuses or contiguous
Intracranial Pyogenic Disease: A Pathological and Clinical Study of the Pathways of Infection from the Face, the Nasal and Paranasal Air-Cavities. JAMA. 1933;100(8):605. doi:10.1001/jama.1933.02740080069039
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