Following the demonstration in 1928 by Beckmann1 and in 1929 by Cohn, McMeekin and Minot2 that liver extract could be given intravenously to patients with pernicious anemia with good therapeutic results, numerous forms of the material have been used with success. The first published formula of a simply prepared product was that of Castle and Taylor3 in 1931. Their solution consisted essentially of liver extract No. 343 N. N. R. washed with ether and dissolved in physiologic solution of sodium chloride. A later modification (Strauss, Taylor and Castle4) was made by using an aqueous solution at a ph of 7.4.
Intensive studies of the blood changes following the intravenous use of Castle and Taylor's solution were made in our laboratories in May, 1931, and were reported in November, 1931.5 As the reactions following this treatment were too severe to make the medicine of routine
ISAACS R, STURGIS CC, GOLDHAMER SM, BETHELL FH. THE USE OF LIVER EXTRACT INTRAVENOUSLY IN THE TREATMENT OF PERNICIOUS ANEMIA. JAMA. 1933;100(9):629–633. doi:10.1001/jama.1933.02740090001001
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