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July 24, 1926


JAMA. 1926;87(4):241. doi:10.1001/jama.1926.92680040002009a

During the winter of 1925-1926 there was noted with considerable frequency an acute infection due presumably to a Streptococcus viridans which was uniformly recovered from the throat and inflammatory exudates. The occurrence of a cutaneous eruption and a predilection to produce hemorrhagic nephritis were the causes of some confusion in differentiating this syndrome from true scarlet fever due to the hemolytic streptococcus. All ages were affected and in many instances most of the members of the same household. The onset was sudden and resembled grip or influenza, with fever of from 101 to 103 F., intense headache, nausea and vomiting. Herpes was absent. The throat was markedly injected, the pulse was rapid out of proportion to the temperature; there were no pulmonary signs throughout the course. A moderate leukocytosis was the rule. In from twenty-four to forty-eight hours an indefinite exanthem appeared over the trunk and to a

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