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July 24, 1926

REAPPEARANCE OF REACTION AT SITE OF PREVIOUS DICK TEST COINCIDENT WITH APPEARANCE OF MEASLES RASH IN A CASE OF MEASLES

JAMA. 1926;87(4):241-242. doi:10.1001/jama.1926.92680040002009b
Abstract

S. F., a man, aged 21, who had not had scarlet fever, had been acting as a test subject for the standardization of scarlet fever toxin and antitoxin, and usually exhibited a typical Dick reaction from 2 to 3 cm. in diameter.

April 6, 1926, he was given, on the anterior surface of the right forearm, two intracutaneous injections of scarlet fever toxin, one containing 5 skin test doses of standard toxin as furnished by the Hygienic Laboratory, Washington, and the other, two inches below, containing 1 skin test dose of test toxin.

At the same time, two intracutaneous injections of 5 skin test doses of toxin were given on the left forearm, each neutralized with scarlet fever antitoxin, the upper injection containing more antitoxin than was sufficient to neutralize the toxin. As neither of the last two sites showed a reaction at the end of forty-eight hours, while the

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