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July 24, 1926


JAMA. 1926;87(4):246. doi:10.1001/jama.1926.02680040034012

Asthma is not difficult to diagnose, but effective treatment has for the most part remained somewhat problematic and haphazard. An advance in our knowledge of the disorder has resulted from the recognition that a considerable number of persons subject to a recurring dyspnea that is more marked in expiration associated with wheezing are hypersensitive to protein. The importance of the allergic factors no longer requires debate; in fact, there are clinicians who would restrict the term asthma to patients in whom evidences of protein sensitization can be elicited. Peshkin 1 has recently warned against taking any narrow view of the possible genesis of asthma. He points out that the various etiologic protein sensitizations are merely exciting factors and not the basic cause of asthma. What disturbed mechanism is primarily responsible for the varied manifestations of allergy in the human being is still unknown. Until such a mechanism is brought to