Several observers have described variations in the strength of the complement fixation reaction in untreated patients with syphilis. Recent studies with both the Kolmer complement fixation and the Kahn precipitation tests for syphilis have shown such a high degree of specificity and sensitiveness that this question seemed worthy of restudy.
It should immediately be noted that this study does not take into consideration the variation in complement fixing and precipitating substances occurring in treated syphilitic patients. It is a well known fact that such variations, particularly in those treated with the arsphenamines, are very common and the rule. This explains the reluctance with which one pronounces "cure" even after prolonged treatment of chronic syphilis; relapses in our experience have been observed as late as one year after the last negative blood complement fixation test. It may be noted further that the conflicting reports not infrequently obtained from different laboratories have
GREENBAUM SS, YAGLE E. DAILY VARIATIONS IN COMPLEMENT FIXATION (KOLMER) AND PRECIPITATION (KAHN) REACTIONS: IN UNTREATED SYPHILITIC PATIENTS. JAMA. 1926;87(5):318–319. doi:10.1001/jama.1926.02680050028011
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: