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Article
August 7, 1926

EFFECT OF INJECTIONS OF DEXTROSE AND OF INSULIN AND DEXTROSE ON BLOOD SUGAR: PRELIMINARY REPORT

JAMA. 1926;87(6):391-392. doi:10.1001/jama.1926.02680060015005
Abstract

For several years we have been interested in the therapeutic administration of dextrose solutions intravenously, both with and without insulin, to patients with nondiabetic acidosis and excessive vomiting of pregnancy. The results that have followed this treatment have been published elsewhere.1 Seriously sick patients of these types are relatively uncommon, and it will be some time before a number sufficient to report can be studied carefully in the manner outlined below. In the meantime, in order to learn more of the mechanism causing these results, it seemed essential to study the effects which these therapeutic procedures have on normal individuals. Two observations, in the course of our work with normal subjects, seem of sufficient interest to report at this time.

Dextrose, 1.75 Gm. per kilogram of body weight, in 10 and 25 per cent solutions was injected intravenously into healthy young men. The 25 per cent solution was given

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