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In the routine laboratory examinations at the Peter Bent Brigham Hospital, it was observed that a large number of diabetic patients in whom there was no reason to suspect a pathologic condition of the gastro-intestinal tract showed a positive benzidine test for occult blood in the feces. It was believed that some other factor than the meat in the diabetic diet might be the cause of this positive reaction, since a larger proportion of diabetic patients than other patients on diets containing meat seemed to give a positive test. Accordingly, various articles in the diets commonly given to diabetic patients were tested both by the benzidine and by the guaiac test. In this way it was found that in addition to the meats a certain vegetable, English marrow, gave apositive benzidine and guaiac test. This marrow has been largely used in diabetic diets because of its bulk
Massee JC. VEGETABLE MARROW AS A CAUSE OF POSITIVE BENZIDINE TESTS IN THE STOOLS OF DIABETIC PATIENTS. JAMA. 1926;87(6):409. doi:10.1001/jama.1926.92680060005009f
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