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March 25, 1933


Author Affiliations

From the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard) of the Boston City Hospital and the Department of Medicine of the Harvard University Medical School.

JAMA. 1933;100(12):875-878. doi:10.1001/jama.1933.02740120013005

It is being increasingly recognized that hypertensive cardiovascular disease is not a primary disturbance of the kidneys. It terminates much more commonly by cardiac failure or cerebral apoplexy than by renal failure. Nevertheless, it usually affects the kidneys to some degree and occasionally enough to produce renal insufficiency and uremia. The importance of determining the state of the renal function in this condition is therefore evident. In a previous paper1 it was concluded that an adequate analysis of kidney function was possible from the results obtained from the following three tests: (1) an examination of the urine for albumin, casts and cells; (2) a determination of the degree of glomerular filtration by an urea or creatinine clearance test; (3) a test for tubular reabsorption by determining the ability of the kidney to concentrate urine. In the present study these tests have been applied to a group of patients suffering