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Article
April 1, 1933

THE SUSCEPTIBILITY OF HEMOLYTIC STAPHYLOCOCCI TO BACTERIOPHAGE

Author Affiliations

NEW HAVEN, CONN.

From the Division of Protobiology, Yale University School of Medicine.

JAMA. 1933;100(13):1014. doi:10.1001/jama.1933.02740130018005
Abstract

A portion of the problems that we are investigating have, because of their nature, led to a study of several polyvalent staphylococcus bacteriophages obtained from various sources. The recent report of Straub and Applebaum1 on commercial bacteriophage products confirms our earlier studies.2

During the past two years we have tested polyvalent staphylococcus bacteriophages on 121 strains of staphylococci isolated from individuals with carbuncles, furuncles, sinusitis, osteomyelitis and staphylococcus septicemia. Seven of these strains of staphylococci, all nonhemolytic, are not susceptible to any of the phages we have used against them. These strains of bacteria were isolated from long-standing cases of furunculosis (one), sinusitis (four) and osteomyelitis (two). All these organisms grow very well on plain Savita medium2 and multiply as rapidly at 20 C. as they do at 35 C.

Seventy-one of the strains produced strong hemolysis of rabbit, guinea-pig or human blood when they were cultivated

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