Cardiac enlargement associated with hypothyroidism was first described by Zondek.1 Ayman, Rosenblum, and Falcon-Lesses2 recently reviewed the subject, collecting reports of twenty-two cases from the literature and reporting two cases of their own. Gotten3 has since reported another case. Cardiac insufficiency was present in some of these patients. The cardiac insufficiency and enlargement disappeared after the administration of thyroid. Digitalis therapy was often given without benefit before the proper diagnosis had been made. The striking result produced by thyroid in this condition is paralleled only by the effect of vitamin B on the cardiac enlargement in beriberi, as described by Aalsmeer4 and others.
This paper will describe another case of hypothyroidism with cardiac enlargement, apparently the twenty-sixth to be reported. The patient also emphasizes the fact that marked hypothyroidism may occur in slender individuals without the typical appearance of myxedema. Further, auricular fibrillation was present. Although
Walker JE. HYPOTHYROIDISM ASSOCIATED WITH CARDIAC ENLARGEMENT ("MYXEDEMA HEART") AND AURICULAR FIBRILLATION. JAMA. 1933;100(13):1025–1027. doi:10.1001/jama.1933.27420130001010
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: