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This comprises a series of ten brief essays on the pathologic physiology of bones, joints, tendons, muscles, bursae, connective tissue, blood vessels, peripheral nerves, and transplants (grafts) of these tissues. The changes in the subcutaneous tissue caused by trauma and seen in sterile and septic inflammation are reviewed. The discussion of the pathologic physiology of bones and joints is of course based on the authors' humoral theory of ossification and bone absorption. "Anything that produces an active hyperemia in bone could be the origin of a process which some day results in arthritis deformans. Traumatism, infection, malformations, none of these are direct causes. Trauma acts on bone by causing a vasomotor disturbance. If there is infection the bacteria or their toxins do not affect directly the synovia or bone, but only through causing a vascular disturbance; there being a local vasomotor disturbance usually in hyperemia. Once such processes are begun,
Physiologie pathologique, chirurgicale; inflammations, effets des traumatismes, Réparation des plaies, greffes, maladies des os, des articulations, des vaisseaux et des nerfs.. JAMA. 1930;95(15):1121. doi:10.1001/jama.1930.02720150061030
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