In 1920, I1 reviewed the literature on agglutination of streptococci found in scarlet fever and showed by means of immune sheep serums that 92 per cent of the streptococci in the acute stage of scarlet fever and 100 per cent of those from erysipelas belonged to distinct biologic groups, which could be differentiated from one another and from the hemolytic streptococci in other infections. These conclusions were reached by the study of opsonification, agglutination, absorption and protection experiments. These and later studies demonstrated that the streptococci specific for scarlet fever began to disappear as early as the second week of the disease, but that they persisted much longer (six weeks) in patients with discharges. It was found that complications beginning after the third week were generally not due to scarlatinal streptococci. Specific scarlet fever streptococci were also isolated from the pus of infections (finger, burn, vaccination lesion and lochia
TUNNICLIFF R. THE IDENTIFICATION OF THE STREPTOCOCCUS OF SCARLET FEVER. JAMA. 1926;87(9):625–628. doi:10.1001/jama.1926.02680090003002
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