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April 8, 1933


Author Affiliations

Madison, Wis.

JAMA. 1933;100(14):1129-1130. doi:10.1001/jama.1933.02740140053031

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[The foregoing letter was referred to Dr. Ewell, who replies:]

To the Editor:  —The writers' exceptions are well taken. These discrepancies had, however, been previously called to my attention by Dr. Harry D. Baernstein of the University of Wisconsin Medical School.Concerning the amino-acid methionine, several of the standard textbooks of physiologic chemistry, unless revised in very recent years, contain little if any reference to this substance. The 1930 edition of Mathews' Physiological Chemistry does not list it in the tabulation of percentage of amino-acids isolated from various proteins, page 136. That this substance may play an important part in cystinuria remains to be determined, and Dr. H. B. Lewis of the University of Michigan has been kind enough to suggest that I employ methionine in some experimental manner in the further studies that I am pursuing. The incorrect formula in my paper should not, of course, have been overlooked

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