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April 15, 1933


Author Affiliations

From the Department of Surgery, University of Chicago.

JAMA. 1933;100(15):1171-1172. doi:10.1001/jama.1933.27420150005009c

Carcinoid tumors of the appendix and small intestine have been repeatedly described in the literature.1 It is generally conceded that these neoplasms arise from the so-called argentaffin cells present in the mucosa.2 Argentaffin cells are also normally present in the stomach and colon.3 As the name implies, these cells, and the carcinoids derived from them, contain cytoplasmic granules capable of reducing ammoniacal silver solutions. This is the cardinal differentiation between true carcinomas and carcinoid tumors.

A review of the literature failed to disclose reports of carcinoid tumors in the stomach. Two cases of carcinoid tumor of the colon were reported by Saltikow:4 one in the sigmoid and one in the anterior wall of the rectal colon. These were reported before the argentaffin nature of carcinoid tumor cells was recognized (Gosset and Masson2); and although Saltikow's illustrations strongly suggest the carcinoid nature of the neoplasms, their