There is abundant clinical and some experimental evidence in support of the statement that certain types of disease of the paranasal sinuses tend to produce peribronchial infections, with resultant chronic bronchitis, asthma and bronchiectasis.
Experimental investigations have been principally directed, as one would suppose, to identifying the lymph channels that drain the sinuses. To this end André, Grünwald and Most endeavored to work out the lymph drainage in cadavers. This work, while very thorough, is open to the criticism that injections were made under great pressure and also that it was necessarily limited in its scope. In my own investigations in association with Ryder, living animals were used—rabbits for the investigation of the maxillary sinus, and cats for the frontal sinus. It was essential to use some substance that would permit us to follow the routes very clearly, and india ink was selected for this purpose. This fluid is a
MULLIN WV. THE RELATION OF PARANASAL SINUS INFECTION TO DISEASE OF THE LOWER RESPIRATORY TRACT. JAMA. 1926;87(10):739–741. doi:10.1001/jama.1926.02680100023006
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