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September 11, 1926


JAMA. 1926;87(11):850-851. doi:10.1001/jama.1926.02680110050018

The researches of recent years have afforded abundant illustration of the tendency of the living organism to maintain an effective neutrality regulation. Accumulation of acid or base in undue amounts is betrayed not primarily by noteworthy changes in the reaction of the circulating fluids of the body, but rather by a physiologic effort to dispose of or neutralize the undesired excesses. Under such circumstances the urine may carry away considerable quantities of acid-reacting compounds. The presence of an unusual amount of acid ions in the blood leads to augmentation of respiration, a process that dispels the volatile carbon dioxide from the system and thus tends to reduce the actual acidity that induced the change. Fixed acidic factors thus leave through the kidneys, while volatile ones find an exit by way of the lungs. The outcome in either event is a tendency toward the restoration of the normal physiologic reaction or

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