My purpose in this communication is to put on record some new observations on the use and effect of thyroid and thyroxin in the treatment of chronic nephrosis. In earlier publications I1 have drawn attention to certain biochemical features present in chronic nephrosis which also appear in myxedema and other hypothyroid states, chief of which are the hypercholesterolemia and the reduced basal metabolism. Other observers, notably Eppinger,2 have pointed out clinical resemblances between these two groups of disease, and I have recorded a case of chronic nephrosis which ultimately developed into a genuine myxedema.3 Moreover, two cases have come under my observation, and I have been informed of a third, in which chronic nephrosis supervened on prolonged irradiation of the neck, involving the chest and thyroid. From these clinical and biochemical studies the conclusion was drawn that the function of the thyroid gland is in some way
EPSTEIN AA. THYROID THERAPY AND THYROID TOLERANCE IN CHRONIC NEPHROSIS. JAMA. 1926;87(12):913–918. doi:10.1001/jama.1926.02680120023007
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