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Article
September 18, 1926

THE CONTROL OF SCARLET FEVER IN INSTITUTIONS: BY ACTIVE IMMUNIZATION WITH TOXIN DETOXIFIED WITH SODIUM RICINOLEATE

JAMA. 1926;87(12):919. doi:10.1001/jama.1926.02680120029008
Abstract

Through the work of the Dicks it has been shown that an active immunity can be established in positive Dick reactors by the injection of scarlet fever streptococcus toxin.

The process of immunization has since been made mild, safe and rapid through proper neutralization of the raw toxin with sodium ricinoleate.1 By means of this method it has been shown that 87 per cent of children under 8 years of age and as high as 77 per cent of older children susceptible to scarlet fever have been made Dick negative in eight days. The rapidity with which the immunity occurred was entirely owing to the large dosage (from 3,000 to 5,000 skin test doses) possible with the neutralized toxin.

An ideal immunizing process has a double aid: 1. To immunize fairly permanently. 2. To preclude the possibility of epidemics thereby.

The apparent immunity established at the end of eight

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