In Reply We agree with Dr Hoffer’s comment emphasizing the long-term benefit of vena cava filter placement seen in the PREPIC study with regard to reducing the risk of recurrent pulmonary embolism.1,2 However, this beneficial effect was counterbalanced by an increased risk of lower-limb deep venous thrombosis, including filter thromboses, even though 50% of the patients were still receiving anticoagulant treatment.2 Thus, vena cava filters were not associated with a decrease in the overall long-term risk of recurrent venous thromboembolism in the PREPIC study.
Mismetti P, Laporte S, Meyer G. Inferior Vena Cava Filter and Recurrent Pulmonary Embolism—Reply. JAMA. 2015;314(7):729–730. doi:10.1001/jama.2015.8012
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