In Reply The findings reported in the JAMA Clinical Evidence Synopsis were based on randomized clinical trials, as was our Cochrane review.1 The comparison of the 2 doses (≥75 mg/d vs <75 mg/d) of zinc was performed as a part of a network meta-analysis, which is a valid technique to assess the comparative effectiveness of interventions among similar study populations that have not been compared directly in randomized clinical trials.2
Das RR, Singh M. Common Cold Treatment Using Zinc—Reply. JAMA. 2015;314(7):730. doi:10.1001/jama.2015.8177
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