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May 6, 1933


JAMA. 1933;100(18):1443-1444. doi:10.1001/jama.1933.02740180065018

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Calmette's Use of B C G Vaccine for Nonallergic Adults  In his previous communications, Calmette has always emphasized that his antituberculous vaccine has only prophylactic value, which is effective only in persons free of all previous tuberculous infection. That is why he recommended at first that the B C G vaccine be used only in the new-born within the first ten days following birth, at which time the intestinal mucosa is not yet differentiated and the immunizing elements can pass directly into the lymphatic system, at a time when the child is not yet a carrier of tubercle bacilli. Others, however, have experimented with the B C G vaccine applied to older children. They have observed the rule to apply it only to persons who do not react to tuberculin. They have secured excellent results by using the subcutaneous route. Mr. Calmette has given his approval to this practice, and,

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