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Featured Clinical Reviews

August 25, 2015

Next-Generation Sequencing and Detection of Minimal Residual Disease in Acute Myeloid Leukemia: Ready for Clinical Practice?

Author Affiliations
  • 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York City, New York
  • 2Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York City, New York
JAMA. 2015;314(8):778-780. doi:10.1001/jama.2015.9452

Acute myeloid leukemia (AML) represents a heterogeneous disease, both with respect to molecular pathogenesis and clinical outcome. Although dose-intensive chemotherapy and allogeneic stem cell transplantation have improved outcomes in AML, there remains significant heterogeneity in clinical outcome such that approximately 20% of patients are cured with existing therapies, 20% have therapy-refractory disease from the time of diagnosis, and 50% relapse and die from refractory disease after an initial response to leukemia therapy.1-4 The challenge is how to best determine prognosis and identify which patients will have a substantive chance of cure, and which patients will likely relapse or present with refractory disease. Current standard of care uses clinical, cytogenetic, and molecular factors for risk stratification; however, there remains a pressing need for better approaches to prognostication in AML.

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