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May 13, 1933

Bacteriophage in the Treatment and Prevention of Cholera.

JAMA. 1933;100(19):1560-1561. doi:10.1001/jama.1933.02740190086039

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This was awarded the Parkin prize for the best essay "on the curative effects of carbonic acid or other forms of carbon in cholera, for different forms of fever and other diseases," by the Council of the Royal College of Physicians of Edinburgh. The author gives an introductory account of John Parkin and his interest in cholera. The main body of the essay is divided into three parts. The first of these is devoted to a description of the bacteriophage, with especial attention to the determination of types, the titration of mixtures of phage and their preparation. The second gives a short statement of the cholera problem in India. The third section, only six and a half pages, describes the therapeutic use of bacteriophage in cholera. Actually a combination of phages active against cholera and dysentery organisms has been used. Although the investigation has been pursued for four years, most

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