The rôle of bacteria, as found in various foci of infection, is extremely important. Although bacteria rarely enter the blood stream under normal conditions, they do harbor and thrive in various crypts, pockets or secluded spots in which there is imperfect drainage and which are therefore called foci. Occasionally, when conditions are suitable, the bacteria acquire enough virulence to invade other regions and then cause disease. Most observers who consider adequately all the facts agree that the bacteria as found in the various foci at times influence other parts of the same body in which they live. This view was voiced by Rush, 1 in 1801, who said, "I have been made happy by discovering that I have only added to the observations of other physicians, in pointing out a connection between the extracting of decayed and diseased teeth and the cure of general disease."
Billings2 has given us
NICKEL AC. THE LOCALIZATION IN ANIMALS OF BACTERIA ISOLATED FROM FOCI OF INFECTION. JAMA. 1926;87(14):1117–1122. doi:10.1001/jama.1926.02680140035009
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