Chiniofon N. N. R., which is sodium iodohydroxyquinolinesulphonate, has been widely exploited under various trademarked names ("yatren," "anayodin") as a relatively nontoxic and supposedly efficient amebacide. It is amazing that there was, until recently, so little critical experimental or clinical study of this compound, especially in comparison with other halogenated oxyquinolines, of which there are many. Why was iodohydroxyquinoline selected for clinical exploitation from those halogenated oxyquinolines available for study when no evidence was furnished that it has demonstrable advantages over the others?
EXPERIMENTAL DATA ON IODOCHLORHYDROXYQUINOLINE
As part of a comprehensive survey of the chemotherapy of amebiasis,1 this compound was compared with hydroxyquinoline and certain of its halogenated derivatives from the standpoint of oral toxicity in guinea-pigs and cats, amebacidal action in vitro, and balantidicidal effect in naturally infested guinea-pigs. We noted an increase in toxicity with increasing halogenation of oxyquinoline and in proportion to the atomic weight
DAVID NA, JOHNSTONE HG, REED AC, LEAKE CD. THE TREATMENT OF AMEBIASIS WITH IODOCHLORHYDROXYQUINOLINE (VIOFORM N. N. R.). JAMA. 1933;100(21):1658–1661. doi:10.1001/jama.1933.02740210006002
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