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May 27, 1933

Fièvre boutonneuse: Fièvre exanthématique du littoral méditerranéen.

JAMA. 1933;100(21):1717. doi:10.1001/jama.1933.02740210065037

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The authors bring together in this treatise the facts at present known about a type of spotted fever of the Mediterranean littoral, a disease first designated as "fièvre boutonneuse" by Conor and Bruch in 1910 in Tunis and to which this name was later restricted by the first International Congress of Hygiene, at Marseilles. The disease is clinically and immunologically distinct from true typhus fevers (epidemic and endemic types), is transmitted by dog ticks (Rhipicephalus sanguineus), and is quite uniformly benign in character. It is a disease of summer, occurring in foci in the country from one year to another. The history of the disease is reviewed, its etiology and epidemiology are discussed, and a description of the clinical studies is given. There are also chapters on the laboratory observations, nosology, prophylaxis and treatment, and an extensive bibliography. It is an important contribution to knowledge of the typhus fevers.

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