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The author presents a plea for further research and inquiry into the problem of the prevention of chronic rheumatism. He summarizes the results of his clinical work during the past five years. He believes three fourths of the victims of chronic rheumatism could have been saved from their suffering if the condition had been recognized early enough. He believes not only that the disease is becoming more common but that its worst features are to be found at an earlier age with each successive generation. "Our parents complained of it at 60 and we ourselves are aware of it soon after 40, whereas it is now common in the rising generation during the 20's." He estimates that one sixth of the working population of the United Kingdom is unable to work on account of chronic rheumatism. He summarizes the infective, metabolic and endocrine theories of etiology. In discussing vaccine therapy,
Chronic Rheumatism and the Pre-Rheumatic State. JAMA. 1933;100(22):1802. doi:10.1001/jama.1933.02740220068047
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