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June 10, 1933


JAMA. 1933;100(23):1867-1868. doi:10.1001/jama.1933.02740230045014

That small amounts of carbohydrate substances may be found in the urine of healthy persons has been frequently established. Part of the carbohydrate has been alleged to be a fermentable compound, while another portion is reported to be nonfermentable by yeast. The knowledge of these facts inevitably has a bearing on the consideration of diabetes; in fact, the problems of this disorder must have some intimate relation to the "normal" sugar excretion, if the latter conception is a justifiable one. The ability to demonstrate a carbohydrate substance in the urine of health depends on the delicacy of the test reactions employed.

In 1918, S. R. Benedict and his co-workers1 reached the conclusion, on the basis of careful investigations, that sugar elimination takes place, in small amounts of course, continuously through the urine. At that time they alleged that progress in the study of carbohydrate metabolism will probably be more